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Powell, Michael D.

One or more keywords matched the following properties of Powell, Michael D.

Property	Value
overview	My research centers around the HIV-1 protein Nef. Our research has shown that Nef protein is secreted by HIV-1 infected cells and is present in the plasma of infected individuals. Our studies suggest that Nef is secreted from cells in the form of exosomes, small membrane bound vesicles approximately 50-100nm in size. T cells that come in contact with Nef exosomes undego apoptosis. Macrophage can take up Nef exosomes, but their affect on these cells is largely unknown. Nef exosomes appear to play a significant role in the pathogenic effects of HIV-1 infection leading to AIDS. Most recently we have worked with Bruce Shiramizu at the U of Hawaii to investigate the potential of Nef exosomes to facilitate the pathogenesis of HIV Associated Neurologic Disorders (HAND). We have also been working with a traditional medicine group called ProMetra. Extracts of natural plants are used to treat HIV/AIDS patients. We have shown that these natural products have the ability to block entry of HIV into T cells. We are interested testing these herbal treatments in a clinical trial. We have recently worked with USAMRIID to also investigate the potential of these herbal treatments to inhibit Ebola virus. In another collaboration we are working with Carol Carter at SUNY Stonybrook to investigate host proteins involved in trafficking of Gag protein in HIV-1. Our most recent work has been investigating the host protein "Sprouty" in viral traffiicking, I am also the director of our local Proteomics facility we perform LC/MS protein identification and Luminex multiplex protein anaysis.. I would be happy to discuss potential projects with anyone looking for a collaborator.

Property

Value

overview

My research centers around the HIV-1 protein Nef. Our research has shown that Nef protein is secreted by HIV-1 infected cells and is present in the plasma of infected individuals. Our studies suggest that Nef is secreted from cells in the form of exosomes, small membrane bound vesicles approximately 50-100nm in size. T cells that come in contact with Nef exosomes undego apoptosis. Macrophage can take up Nef exosomes, but their affect on these cells is largely unknown. Nef exosomes appear to play a significant role in the pathogenic effects of HIV-1 infection leading to AIDS. Most recently we have worked with Bruce Shiramizu at the U of Hawaii to investigate the potential of Nef exosomes to facilitate the pathogenesis of HIV Associated Neurologic Disorders (HAND). We have also been working with a traditional medicine group called ProMetra. Extracts of natural plants are used to treat HIV/AIDS patients. We have shown that these natural products have the ability to block entry of HIV into T cells. We are interested testing these herbal treatments in a clinical trial. We have recently worked with USAMRIID to also investigate the potential of these herbal treatments to inhibit Ebola virus. In another collaboration we are working with Carol Carter at SUNY Stonybrook to investigate host proteins involved in trafficking of Gag protein in HIV-1. Our most recent work has been investigating the host protein "Sprouty" in viral traffiicking, I am also the director of our local Proteomics facility we perform LC/MS protein identification and Luminex multiplex protein anaysis.. I would be happy to discuss potential projects with anyone looking for a collaborator.

One or more keywords matched the following items that are connected to Powell, Michael D.

Item Type	Name
Academic Article	Genetic characterization of HIV type 1 Nef-induced vesicle secretion.
Academic Article	Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.
Academic Article	Peptide-based identification of functional motifs and their binding partners.
Academic Article	Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A?(1-42) secretion in SH-SY5Y neural cells.
Academic Article	Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells.
Academic Article	Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.
Academic Article	Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer.
Concept	Gene Products, nef
Concept	nef Gene Products, Human Immunodeficiency Virus
Academic Article	Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.
Academic Article	Characterization of Nef-CXCR4 interactions important for apoptosis induction.
Academic Article	HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions.
Academic Article	Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice.
Academic Article	HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals.
Academic Article	Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.
Academic Article	Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial-to-mesenchymal transition in colon and breast cancers.

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Gene Products nef